This document reflects emerging clinical and scientific advances as of the date issued and is subject to change. The information should not be construed as dictating an exclusive course of treatment or procedure to be followed.
The potency Units of BOTOX (onabotulinumtoxinA) for injection are specific to the preparation and assay method utilized. They are not interchangeable with other preparations of botulinum toxin products and, therefore, units of biological activity of BOTOX cannot be compared to nor converted into units of any other botulinum toxin products assessed with any other specific assay method see Warnings and Precautions ( 5.1 ) and Description ( 11 ).
When you arrive at your doctor’s office for your BOTOX® treatment, you will first be asked to fill out patient information and other forms. Then you will meet with your doctor or a trained staff member to discuss your expectations for the procedure. At this time, it is important to be honest about any allergies or other conditions that may not make you a good candidate for BOTOX® treatment.
The Anticholinergic vs OnabotulinumtoxinA Comparison study was a multicenter randomized trial that compared the effectiveness of 6 months of daily anticholinergic therapy with a single intradetrusor injection of 100 units of onabotulinumtoxinA in patients with overactive bladder symptoms ( 5 ). The study included participants who had never taken anticholinergic medications and those who had taken two or fewer prior anticholinergic medications. Results demonstrated Botox specials Las Vegas that anticholinergics had similar rates of improvement in symptoms of overactive bladder compared with onabotulinumtoxinA injections. However, patients who underwent onabotulinumtoxinA injections had significantly higher cure rates compared with patients who received anticholinergic medication. Risk of voiding dysfunction that required catheterization and urinary tract infection in women who received onabotulinumtoxinA injection was 5% and 33%, respectively.
The injections are performed in the office with an ultra-fine needle and the number of injections required varies with the degree of wrinkling. Many patients receive BOTOX® Cosmetic injections on their lunch hour and return to work. The effects of BOTOX® Cosmetic begin between 24-72 hours and the effect lasts an average of 3 months. There is some evidence that after several repeated injections, the effects last longer. Typically, patients over the age of 65 may not experience as significant results and thus is not used to repair sagging skin caused by normal aging.
Today, numerous medical conditions seen in a spine and pain management setting are being treated with botulinum toxin. Some examples include: cervical dystonia, chronic headaches, chronic myofascial pain, thoracic and lumbar spine myofascial pain , post-laminectomy pain syndrome, spasticity, focal dystonias, piriformis syndrome and chronic neurogenic pain.